Journal: Beilstein Journal of Nanotechnology

Article Title: Fabrication and testing of polymer microneedles for transdermal drug delivery

doi: 10.3762/bjnano.13.55

Figure Lengend Snippet: a) 2D axisymmetric meshing for three-layer skin model and single MN model, b) von-Mises stress result of the penetration region and the associated skin deflection surrounding the MN insertion. Force-displacement graph recorded during insertion based on c) FEA Explicit Dynamics simulation, and d) in vitro experiment using a BD Ultra-Fine™ 4 mm Pen Needle on porcine skin.

Article Snippet: To determine the MN and skin interactions during the penetration, a 2D axisymmetric simulation model was performed using ANSYS (2020 R1, ANSYS, Canonsburg, Pennsylvania, USA) Explicit Dynamics.

Techniques: In Vitro

Journal: Scientific Reports

Article Title: Kinetic modelling of ultrasound-triggered chemotherapeutic drug release from the surface of gold nanoparticles

doi: 10.1038/s41598-023-48082-9

Figure Lengend Snippet: The 2D axisymmetric geometry used for COMSOL simulation in this study. The LIPUS piston transducer is defined as a flat line, while the water, dialysis membrane, nylon clip, and acrylic holder domains are labelled for reference. The bottom of the dialysis chamber setup is an acoustic absorber and defined as a PML. PMLs are also set on the outside of the dialysis chamber walls, as no significant reflection from outside the chamber is considered.

Article Snippet: The COMSOL pressure acoustics simulation produced 2D axisymmetric pressure and intensity fields inside the dialysis chamber, as seen in Fig. A,B.

Techniques: Membrane

Journal: Scientific Reports

Article Title: Kinetic modelling of ultrasound-triggered chemotherapeutic drug release from the surface of gold nanoparticles

doi: 10.1038/s41598-023-48082-9

Figure Lengend Snippet: COMSOL simulated 2D ( A ) pressure and ( B ) time-averaged intensity fields inside the dialysis chamber. The LIPUS element, dialysis membrane, acrylic chamber walls, and nylon closure clips are marked for reference. ( C ) The ARF axial profile through the center of the dialysis membrane.

Article Snippet: The COMSOL pressure acoustics simulation produced 2D axisymmetric pressure and intensity fields inside the dialysis chamber, as seen in Fig. A,B.

Techniques: Membrane